In the hostile environment of the volcanic islands of Galapagos, where extreme heat and poor soil challenge plant life, wild tomatoes are growing and surprising science. Far from evolving towards more modern forms, these plants are recovering biochemical traits that were believed to be extinct.
Researchers from international universities discovered that some wild tomato species are producing ancient chemical compounds, similar to those of their ancestors. This is a documented case of “reverse evolution”, a phenomenon that challenges traditional linear models of evolutionary development.
These plants are not mutating randomly: they are activating ancient genes to generate defensive alkaloids that do not appear in modern varieties. It’s as if they are unlocking a forgotten biological file, useful for surviving in an extremely adverse environment.
The key would lie in their environment. The youngest islands in the archipelago, such as Fernandina and Isabela, impose severe environmental pressure. There, tomatoes reproduce prehistoric chemical defenses as a survival strategy against a hostile environment.

Ancestral Plant Defense Returns
The study focused on wild species Solanum cheesmaniae and Solanum galapagense, descendants of South American tomatoes. Scientists analyzed their genetics and found that these plants can synthesize alkaloids in a very similar way to how they did millions of years ago.
The stereochemistry of these compounds, that is, their three-dimensional structure, is key. Although they contain the same atoms as modern alkaloids, their arrangement completely changes their function, turning them into potent natural defenses.
This phenomenon is the result of just four mutations in the sequence of an essential enzyme. These minimal changes are enough to reactivating a biochemical pathway that seemed extinct, reversing the plant’s evolutionary course.
Laboratory experiments confirmed that by introducing these ancient genes into other plant species, such as tobacco, they can also produce prehistoric alkaloids. This reinforces the idea that evolutionary paths from the past are still present in current genomes, waiting to be reactivated.
Nature Looking Back to Move Forward
This finding not only expands the understanding of evolution but also opens new perspectives for agricultural biotechnology. If it is possible to reactivate ancestral chemical pathways with just a few genetic adjustments, more resistant crops could be designed without resorting to synthetic products.
The extreme conditions of Galapagos seem to have acted as a catalyst for this evolutionary reversal. It suggests that, facing climate change and environmental pressure, other species could follow similar paths.
Evolution is not an arrow pointing to the future but a flexible process that also recovers ancient solutions when they are most effective. In these resilient tomatoes, life shows us that, in certain contexts, the best way forward may be to return to the origin.

A Beneficial Food for Health and the Environment
Tomato is a rich source of essential nutrients such as vitamin C, potassium, folic acid, and antioxidants like lycopene, which helps prevent cardiovascular diseases and some types of cancer. Its high water content also makes it a hydrating food with low caloric content.
From an environmental perspective, tomato cultivation can adapt to different regions and sustainable production systems, especially when using organic farming techniques and efficient water management. Its resistance to different climatic conditions makes it viable in family and community gardens.
Being a crop with a relatively short cycle, it allows frequent soil rotation and can be integrated into agroecological systems that reduce the use of agrochemicals. Thus, the tomato not only contributes to food security but can also be part of agricultural practices that are more environmentally responsible.



